Lipopeptide 10mg

Lipopeptide 10mg

Lipopeptide 10mg

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30044
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Lipopeptide is a molecule consisting of a lipid chain connected to an oligopeptide chain, typically comprised of five amino acid residues when applied in cosmetic settings1. In animal trials, Lipopeptide has been shown to stimulate the production of natural collagen, elastin, and hyaluronic acid (HA) in existing skin2. With action mainly at the site of the extracellular matrix of dermal cells, Lipopeptide activates cellular production through Toll-like Receptor 1 (TLR1) and a multitude of other TLRs3.

Description

Lipopeptide is a molecule consisting of a lipid chain connected to an oligopeptide chain, typically comprised of five amino acid residues when applied in cosmetic settings1. In animal trials, Lipopeptide has been shown to stimulate the production of natural collagen, elastin, and hyaluronic acid (HA) in existing skin2. With action mainly at the site of the extracellular matrix of dermal cells, Lipopeptide activates cellular production through Toll-like Receptor 1 (TLR1) and a multitude of other TLRs3.

Through interaction with dermal barriers, Lipopeptide has been found to increase the aqueous content of skin, allowing for enhanced moisture-binding properties. The Lipopeptide-induced increase in elastin production allows for the reduction of microgroove production and for the enhancement of the skin’s elastic properties, thereby acting to repair the effects of age-related skin damage4.

Product Comparison

Lipopeptide has been found to be one of the most effective and biocompatible agents for skin anti-aging action in existence. Unlike other water-soluble cosmeceuticals, Lipopeptide has been found to conform very well to skin’s natural structure, allowing for strong adhesion and skin rejuvenating effects in animal test subjects3.

Synonyms: Glyceryl Polymethacrylate; PEG-8; Palmitoyl Oligopeptide; Biopeptide EL;

Peer-Reviewed Sources:

(1) Kadereit, D. and Waldmann H. Chemoenzymatic synthesis of lipidated peptides. Monatshefte Chemie. 2000;131:571-584.

(2) Fields, K. Falla T. J. Rodan K. and Bush L. Bioactive peptides: signaling the future. Journal of Cosmetic Dermatology. 2009;8:8-13.

(3) Zhang, L. and Falla T. J. Cosmeceuticals and peptides. Clinics in Dermatology. 2009;27:485-494.

(4) Robinson, L. R. Fitzgerald N. C. Doughty D. G. Dawes N. C. Berge C. A. and Bissett D. L. Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin. International Journal of Cosmetic Science. 2005;27:155-160.

More Information
CAS Number 171263-26-6
Molecular Formula C38H68N6O8
Residue Sequence Pal-Gly-Gln-Pro-Arg-OH
Molar Mass 736.98 g/mol
Specificity Lipopeptide has an affinity for the TLR1 or other Toll-like receptors.
Physical Appearance Fine White Lyophilized Powder
Solubility 100 μg/mL sterile diluent (distilled de-ionized water)
Stability Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C.
Source Biosynthetic production
This product is prepared for LABORATORY RESEARCH USE ONLY and may not be used for other purposes.