CJC-1295 no DAC is a synthetic peptide developed to be an analogy of growth hormone releasing hormone (GHRH)1. The 29 amino acid sequence is derived from GRF(1-29), a naturally occurring growth hormone releasing factor. As its name implies, CJC-1295 no DAC lacks the ‘drug affinity complex’ described below2. This structural difference infers a shorter peptide half-life than its DAC-inclusive counterpart, which is elicits a GH release profile that more closely reflects what occurs in nature.
CJC-1295 no DAC is reported to be a potent agent for the stimulation of pulsatile growth hormone (GH) and IGF-1 release3. These biochemical actions have been shown to result in the promotion of lean body mass, enhanced strength, increased appetite, and an improved quality of sleep in animal test subjects4.
In spite of having a similar site of action, CJC-1295 no DAC (and CJC-1295 DAC) does not stimulate GH production using the same biochemical pathway as the popular GH secretagogue GHRP-66. In light of this observation, it has been possible for researchers to administrate CJC-1295 species and GHRP-6 concurrently in order to achieve an additive positive effect on GH release.
Drug Affinity Complex
The drug affinity complex (DAC) is a chemical group fixed to CJC-1295 DAC that helps the peptide escape degradation by natural enzymes. By adding a component that gives CJC-1295 an affinity for albumin2, a naturally occurring protein in blood plasma, the peptide can achieve a much longer systemic half-life.
Preference for a long or short peptide half-life depends entirely on the research application of these agents.
Synonyms: CJC-1295; CJC-1295 no DAC; CJC-1295 without DAC; Modified Growth Releasing Factor aminos 1-29; Modified GRF (1-29); Mod GRF 1-29; Tetrasubstituted GRF (1-29);
|Molar Mass||3367.89 g/mol|
|Specificity||Like its naturally occurring analogy GHRH, CJC-1295 no DAC has an affinity for the GHRH receptor.|
|Physical Appearance||Fine White Lyophilized Powder|
|Solubility||100 μg/mL sterile diluent (distilled de-ionized water)|
|Stability||Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C.|