Thymosin Beta 4 (TB500)

Thymosin Beta 4 (TB500)

Thymosin Beta 4 (TB500)

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Thymosin Beta 4 (TB500)

TB-500 is a synthetic analogue to a naturally occurring protein present in most kinds of mammalian tissue1. TB-500 is an active mediating agent in cellular proliferation and differentiation processes2. Researchers have found that TB-500 is a potent promoter of wound healing3 and modulator of the inflammatory response of animal test subjects4. Through its action of regulating the production of actin, an important cellular component involved in structure and movement of all cells, TB-500 is an agent with a broad spectrum of beneficial capabilities.

Description

TB-500 is a synthetic analogue to a naturally occurring protein present in most kinds of mammalian tissue1. TB-500 is an active mediating agent in cellular proliferation and differentiation processes2. Researchers have found that TB-500 is a potent promoter of wound healing3 and modulator of the inflammatory response of animal test subjects4. Through its action of regulating the production of actin, an important cellular component involved in structure and movement of all cells, TB-500 is an agent with a broad spectrum of beneficial capabilities.

Muscle Repair and Maintenance

TB-500 has been researched extensively in the areas of muscle and connective tissue repair5. TB-500 has been shown to stimulate the overproduction of regenerative fibers following injury, thereby speeding the process of recovery with minimal inflammation and residual scarification.

TB-500’s property of enhancing muscle growth in both healthy and damaged tissues has led to its application as an experimental therapeutic in animal test subjects with muscular dystrophy6. Regular administration of TB-500 allowed animal test subjects with muscular dystrophy to achieve much improved maintenance of muscle growth and development, even in the absence of important, naturally occurring proteins that usually guide this action.

TB500 has also been researched to be an aid in the healing of heart tissue following heart attack7 and as a very powerful agent for quickly healing skin abrasions. TB500’s angiogenic (blood vessel-forming) properties8 are responsible for its excellent application in these areas.

Synonyms: Thymosin Beta 4; TB500

Peer-Reviewed Sources:

(1) Safer, D., Elzinga, M., & Nachmias, V. T. (1991). Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable. Journal of Biological Chemistry, 266(7), 4029-4032.

(2) Grant, D. S., Kinsella, J. L., Kibbey, M. C., LaFlamme, S., Burbelo, P. D., Goldstein, A. L., & Kleinman, H. K. (1995). Matrigel induces thymosin beta 4 gene in differentiating endothelial cells. Journal of cell science, 108(12), 3685-3694.

(3) Malinda, K. M., Sidhu, G. S., Mani, H., Banaudha, K., Maheshwari, R. K., Goldstein, A. L., & Kleinman, H. K. (1999). Thymosin β4 accelerates wound healing. Journal of investigative dermatology, 113(3), 364-368.

(4) Sosne, G., Szliter, E. A., Barrett, R., Kernacki, K. A., Kleinman, H., & Hazlett, L. D. (2002). Thymosin beta 4 promotes corneal wound healing and decreases inflammation in vivo following alkali injury. Experimental eye research,74(2), 293-299.

(5) Blain, E. J., Mason, D. J., & Duance, V. C. (2002). The effect of thymosin beta4 on articular cartilage chondrocyte matrix metalloproteinase expression. Biochemical Society Transactions, 30(Pt 6), 879-882.

(6) Spurney, C. F., Cha, H. J., Sali, A., Pandey, G. S., Pistilli, E., Guerron, A. D., & Nagaraju, K. (2010). Evaluation of Skeletal and Cardiac Muscle Function after Chronic Administration of Thymosin β-4 in the Dystrophin Deficient Mouse. PloS one, 5(1), e8976.

(7) Crockford, D. (2007). Development of thymosin β4 for treatment of patients with ischemic heart disease. Annals of the New York Academy of Sciences, 1112(1), 385-395.

(8) Smart, N., Rossdeutsch, A., & Riley, P. R. (2007). Thymosin β4 and angiogenesis: modes of action and therapeutic potential. Angiogenesis, 10(4), 229-241.

More Information
CAS Number 77591-33-4
PubChem CID 16132341
Molecular Formula C212H350N56O78S
Residue Sequence Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser
Molar Mass 4963.44 g/mol
Specificity TB-500 acts specifically to regulate actin production and polymerization.
Physical Appearance Fine White Lyophilized Powder
Solubility 100 μg/mL sterile diluent (distilled de-ionized water)
Stability Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C.
Source Biosynthetic production
This product is prepared for LABORATORY RESEARCH USE ONLY and may not be used for other purposes.